Science Friday: Miscarriage and heart disease connection

Pregnancy loss, cardiovascular disease connected by new study

July 16, 2014

The Annals of Family Medicine published an article detailing research showing that women with a history of pregnancy loss are at higher risk for cardiovascular disease later in adulthood than other women, work completed by physicians in the Center for Primary Care and Prevention (CPCP) at Memorial Hospital of Rhode Island.
Related Articles

The article “Risk of Cardiovascular Disease Among Postmenopausal Women with Prior Pregnancy Loss: The Women’s Health Initiative” stems from the analysis of data from the maternity experiences of a sample of 77,701 women, according to Donna Parker, ScD, director for community health and research with the CPCP. Of those, 30.3 percent reported a history of miscarriage, 2.2 percent a history of stillbirth, and 2.2 percent a history of both.

“We found that the adjusted odds for coronary heart disease in women who had one or more stillbirths was 1.27 (95 percent confidence interval (CI), which is a measure of reliability, 1.07-1.51) compared with women who had no stillbirths,” Dr. Parker says. “For women with a history of one miscarriage, the odds ratio was 1.19 (95 percent CI, 1.08-1.32). For women with a history of two or more miscarriages, the odds ratio was 1.18 (95 percent CI, 1.04-1.34) compared with no miscarriage.”

The researchers found no significant association of ischemic stroke and pregnancy loss, she adds. The association between pregnancy loss and coronary heart disease appeared to be independent of hypertension, body mass index, waist-to-hip ratio and white blood cell count.

“These findings contribute to the growing body of evidence that the metabolic, hormonal and hemostatic pathway alterations that are associated with a pregnancy loss may contribute to the development of coronary heart disease in adulthood,” Dr. Parker continues.

Women with a history of miscarriage or a single stillbirth should be closely monitored and receive early intervention from their primary care physician so risk factors such as diabetes, hypertension, cholesterol, obesity, smoking and diet can be closely monitored and controlled.

Journal Reference:

D. R. Parker, B. Lu, M. Sands-Lincoln, C. H. Kroenke, C. C. Lee, M. O’Sullivan, H. L. Park, N. Parikh, R. S. Schenken, C. B. Eaton. Risk of Cardiovascular Disease Among Postmenopausal Women with Prior Pregnancy Loss: The Women’s Health Initiative. The Annals of Family Medicine, 2014; 12 (4): 302 DOI: 10.1370/afm.1668

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s